Beilstein J. Nanotechnol.2014,5, 2293–2307, doi:10.3762/bjnano.5.238
the effectiveness of PTX alone (p < 0.036). Above all, the DDMC/PTX complex is not degraded in cells and acts as an intact supramolecular assembly, which adds a new species to the range of DDS.
Keywords: artificial enzyme; diethylaminoethyl–dextran–MMA; graft copolymer; multi-drugresistanceof
cancercells; paclitaxel; supramolecular complex; Review
Introduction
As a means of delivering a drug to a target effectively, the enhanced permeation and retention (EPR) effect and reticuloendothelial system (RES) were enabled by using a polymer drug delivery system (DDS), and it is thought to
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Figure 1:
Non-viral vectoring of DEAE–dextran and DEAE–dextran–MMA graft copolymer (DDMC). (a) Transfection o...